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Article

Phenotypic effects of targeted mutations in the small subunit rRNA gene of Tetrahymena thermophila.

Molecular and cellular biology - 1 Aug 1993

Sweeney R, Chen L, Yao M C

Abstract excerpt

Tetrahymena thermophila is an ideal organism with which to study functional aspects of the rRNAs in vivo since the somatic rRNA genes of T. thermophila can be totally replaced by cloned copies introduced via microinjection. In this study, we made small insertions into seven sites within the small subunit rRNA gene and observed their phenotypic effects on transformed cells. Two mutated genes coding for rRNA...

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Identifiers

PMID: 8336718
DOI: 10.1128/mcb.13.8.4814-4825.1993
PMCID: PMC360108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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