An rRNA variable region has an evolutionarily conserved essential role despite sequence divergence.

doi:10.1128/mcb.14.6.4203-4215.1994

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Article

An rRNA variable region has an evolutionarily conserved essential role despite sequence divergence.

Molecular and cellular biology - 1 Jun 1994

Sweeney R, Chen L, Yao M C

Abstract excerpt

Regions extremely variable in size and sequence occur at conserved locations in eukaryotic rRNAs. The functional importance of one such region was determined by gene reconstruction and replacement in Tetrahymena thermophila. Deletion of the D8 region of the large-subunit rRNA inactivates T. therm...

Topics

Animals
Base Sequence
Biological Evolution
Caenorhabditis elegans
Conserved Sequence
Crosses, Genetic
DNA Primers
DNA, Ribosomal
Dictyostelium
Genetic Variation
Models, Structural
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Nucleic Acid Conformation

Polymerase Chain Reaction

RNA, Ribosomal

Restriction Mapping

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 8196658
DOI: 10.1128/mcb.14.6.4203-4215.1994
PMCID: PMC358786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8196658-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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