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Article

An rRNA variable region has an evolutionarily conserved essential role despite sequence divergence.

Molecular and cellular biology - 1 Jun 1994

Sweeney R, Chen L, Yao M C

Abstract excerpt

Regions extremely variable in size and sequence occur at conserved locations in eukaryotic rRNAs. The functional importance of one such region was determined by gene reconstruction and replacement in Tetrahymena thermophila. Deletion of the D8 region of the large-subunit rRNA inactivates T. thermophila rRNA genes (rDNA): transformants containing only this type of rDNA are unable to grow. Replacement with an...

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Identifiers

PMID: 8196658
DOI: 10.1128/mcb.14.6.4203-4215.1994
PMCID: PMC358786

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