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Influenza A virus haemagglutinin polymorphism: pleiotropic antigenic variants of A/Shanghai/11/87 (H3N2) virus selected as high yield reassortants.

The Journal of general virology - 1 Jul 1993

Kilbourne E D, Johansson B E, Moran T, Wu S, Pokorny B A, Xu X, Cox N

Abstract excerpt

Genetic reassortment of the A/Shanghai/11/87 (H3N2) variant of influenza A virus with A/PR8/34 (H1N1) virus [the standard donor of high yield (hy) genes for influenza vaccine viruses] resulted in the isolation of two reassortants with differing H3 haemagglutinin (HA) phenotypes, X-99 and X-99a. The two HA phenotypes were derived from individual subpopulations of the H3N2 wild-type virus during the reassortment...

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PMID: 8336120
DOI: 10.1099/0022-1317-74-7-1311

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