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Article

Phenotypic expression of HA-NA combinations in human-avian influenza A virus reassortants.

Archives of virology - 1 Jan 1996

Rudneva I A, Sklyanskaya E I, Barulina O S, Yamnikova S S, Kovaleva V P, Tsvetkova I V, Kaverin N V

Abstract excerpt

Human-avian and human-mammalian influenza A virus reassortant clones with the neuraminidase (NA) gene of the A/USSR/90/77 (H1N1) strain and hemagglutinin (HA) genes of H3, H4 and H13 subtypes had been shown in an earlier publication to produce low HA yields in the embryonated chicken eggs. The low HA titers had been shown to be due, at least in part, to the formation of virion clusters at 4 degrees C; the...

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PMID: 8712926
DOI: 10.1007/BF01718612

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