Article
Intergenic HA-NA interactions in influenza A virus: postreassortment substitutions of charged amino acid in the hemagglutinin of different subtypes.
Virus research - 1 Feb 2000
Kaverin N V, Matrosovich M N, Gambaryan A S, Rudneva I A, Shilov A A, Varich N L, Makarova N V, Kropotkina E A, Sinitsin B V
Abstract excerpt
In our previous studies influenza A virus reassortants having neuraminidase (NA) gene of A/USSR/90/77 (H1N1) strain and hemagglutinin (HA) genes of H3, H4 and H13 subtypes were shown to produce a low virus yield and to exhibit a strong tendency to virion aggregation. More detailed studies with the use of a H3N1 reassortant and its high-yield non-aggregating variants revealed that NA of A/USSR/90/77 strain is...
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