Nonimmunoselected intrastrain genetic variation detected in pairs of high-yielding influenza A (H3N2) vaccine and parental viruses.

doi:10.1093/infdis/170.6.1432

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Article

Nonimmunoselected intrastrain genetic variation detected in pairs of high-yielding influenza A (H3N2) vaccine and parental viruses.

The Journal of infectious diseases - 1 Dec 1994

Xu X, Kilbourne E D, Hall H E, Cox N J

Abstract excerpt

Seven influenza A (H3N2) high-yielding vaccine candidate strains were examined. Antigenic analysis revealed that 5 of the strains could be distinguished antigenically from their corresponding wild type parent viruses. Comparative sequence data for the HA1 domains of the HA (hemagglutinin) genes for these 5 high-yielding viruses and the corresponding wild type parents demonstrated one to three amino acid...

Topics

Amino Acid Sequence
Base Sequence
Genes, Viral
Genetic Variation
Hemagglutination Inhibition Tests
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral
Humans
Influenza A Virus, H3N2 Subtype
Influenza A virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza Vaccines

Molecular Sequence Data

RNA, Viral

Reassortant Viruses

Sequence Analysis, DNA

Viral Structural Proteins

Source

Open in PubMed

Identifiers

PMID: 7995982
DOI: 10.1093/infdis/170.6.1432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7995982-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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