Article
[In vitro ENU-induced carcinogenesis of rat fetal astroglia--biological character of mutant glial cell].
No to shinkei = Brain and nerve - 1 Apr 1993
Hiraga S, Arita N, Ohnishi T, Taki T, Yamamoto H, Higuchi M, Hayakawa T
Abstract excerpt
To investigate glial carcinogenesis in vitro, fetal rat brain cells were cultured and exposed to ENU (approximately 200 micrograms/ml). The cells were passaged weekly thereafter. Morphological changes were observed under the phase contrast microscope. When mutant colonies where the cells lost con...
Topics
- Animals
- Astrocytes
- Brain
- Brain Neoplasms
- Cells, Cultured
- Ethylnitrosourea
- Fetus
- Flow Cytometry
- Mice
- Mice, Nude
- Mutation
- Neoplasm Transplantation
- Rats