Article
[Instability of cell phenotype and tumor initiating cells in gliomas].
Biologie aujourd'hui - 1 Jan 2011
Junier Marie-Pierre, Sharif Ariane
Abstract excerpt
Gliomas, the most frequent primitive CNS tumors, have been suggested to originate from astrocytes or from neural progenitors/stem cells. However, the precise identity of the cells at the origin of gliomas remains a matter of debate because no pre-neoplastic state has been yet identified. TGFα, an EGF family member, is frequently over-expressed in the early stages of glioma progression. We questioned whether...
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