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Article

Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model.

Oncology reports - 1 Dec 2009

Gagliano Nicoletta, Costa Francesco, Cossetti Chiara, Pettinari Letizia, Bassi Rosaria, Chiriva-Internati Maurizio, Cobos Everardo, Gioia Magda, Pluchino Stefano

Abstract excerpt

As the majority of gliomas arise through malignant transformation of astrocytes, we aimed at investigating the interaction between malignant glioma cells and astrocytes in a co-culture experimental model. For this purpose we analyzed the expression of genes and proteins involved in tumor promotion and invasion, such as glial fibrillary acidic protein (GFAP), matrix metalloproteinase-2 (MMP-2), tissue inhibitor of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19885586
DOI: 10.3892/or_00000574

Genes

SPARC
GFAP
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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