Article
Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally.
Nature - 22 Jul 1993
Hamelin M, Zhou Y, Su M W, Scott I M, Culotti J G
Abstract excerpt
Growth cones in developing nervous systems encounter a sequence of extracellular cues during migration. In theory, a growth cone can navigate by selectively expressing or activating surface receptor(s) that recognize extracellular cues appropriate to each migratory phase. Using the simple Caenorh...
Topics
- Animals
- Animals, Genetically Modified
- Axons
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Movement
- Genes, Helminth
- Helminth Proteins
- Membrane Proteins
- Mutation
- Neurons
- Receptors, Cell Surface