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Article

Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally.

Nature - 22 Jul 1993

Hamelin M, Zhou Y, Su M W, Scott I M, Culotti J G

Abstract excerpt

Growth cones in developing nervous systems encounter a sequence of extracellular cues during migration. In theory, a growth cone can navigate by selectively expressing or activating surface receptor(s) that recognize extracellular cues appropriate to each migratory phase. Using the simple Caenorhabditis elegans nervous system, we attempted to demonstrate that path selection by migrating growth cones can be...

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PMID: 8332188
DOI: 10.1038/364327a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally.PMID 8332188Read ↗

Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.Semantic proximity Read ↗

Axon guidance mechanisms in Caenorhabditis elegans.Semantic proximity Read ↗

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans.Semantic proximity Read ↗

Genetic analysis of growth cone migrations in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans.Semantic proximity Read ↗

wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background.Semantic proximity Read ↗

ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.Semantic proximity Read ↗

Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon position.Semantic proximity Read ↗

Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity.Semantic proximity Read ↗

UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans.Semantic proximity Read ↗

Genes that guide growth cones along the C. elegans ventral nerve cord.Semantic proximity Read ↗

ENU-3 is a novel motor axon outgrowth and guidance protein in C. elegans.Semantic proximity Read ↗

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