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Article

UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans.

Development (Cambridge, England) - 1 Oct 2011

Norris Adam D, Lundquist Erik A

Abstract excerpt

The UNC-6/netrin guidance cue functions in axon guidance in vertebrates and invertebrates, mediating attraction via UNC-40/DCC family receptors and repulsion via by UNC-5 family receptors. The growth cone reads guidance cues and extends lamellipodia and filopodia, actin-based structures that sense the extracellular environment and power the forward motion of the growth cone. We show that UNC-6/netrin, UNC-5 and...

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Identifiers

PMID: 21880785
DOI: 10.1242/dev.068841
PMCID: PMC3177313

Genes

DCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans.PMID 21880785Read ↗

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Identification of domains of netrin UNC-6 that mediate attractive and repulsive guidance and responses from cells and growth cones.Semantic proximity Read ↗

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UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites.Semantic proximity Read ↗

Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.Semantic proximity Read ↗

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Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally.Semantic proximity Read ↗

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