Article
wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background.
Genetics - 2 Mar 2023
Feresten Abigail H, Bhat Jaffar M, Yu Alex J, Zapf Richard, Rankin Catharine H, Hutter Harald
Abstract excerpt
During nervous system development, neurons send out axons, which must navigate large distances to reach synaptic targets. Axons grow out sequentially. The early outgrowing axons, pioneers, must integrate information from various guidance cues in their environment to determine the correct direction of outgrowth. Later outgrowing follower axons can at least in part navigate by adhering to pioneer axons. In...
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