Article
Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon position.
Neuron - 13 May 2004
Bülow Hannes E, Boulin Thomas, Hobert Oliver
Abstract excerpt
Wiring of the nervous system requires that axons navigate to their targets and maintain their correct positions in axon fascicles after termination of axon outgrowth. We show here that the C. elegans fibroblast growth factor receptor (FGFR), EGL-15, affects both processes in fundamentally distinct manners. FGF-dependent activation of the EGL-15 tyrosine kinase and subsequently the GTPase LET-60/ras is required...
Topics
- Animals
- Animals, Genetically Modified
- Axons
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Differentiation
- Motor Neurons
- Mutation
- Receptors, Fibroblast Growth Factor