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Article

Direct link between RACK1 function and localization at the ribosome in vivo.

Molecular and cellular biology - 1 Mar 2009

Coyle Scott M, Gilbert Wendy V, Doudna Jennifer A

Abstract excerpt

The receptor for activated C-kinase (RACK1), a conserved protein implicated in numerous signaling pathways, is a stoichiometric component of eukaryotic ribosomes located on the head of the 40S ribosomal subunit. To test the hypothesis that ribosome association is central to the function of RACK1 in vivo, we determined the 2.1-A crystal structure of RACK1 from Saccharomyces cerevisiae (Asc1p) and used it to design...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19114558
DOI: 10.1128/MCB.01718-08
PMCID: PMC2648249

Genes

RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Direct link between RACK1 function and localization at the ribosome in vivo.PMID 19114558Read ↗

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Asc1p, a WD40-domain containing adaptor protein, is required for the interaction of the RNA-binding protein Scp160p with polysomes.Semantic proximity Read ↗

Association of RACK1 protein with ribosomes in <i>Plasmodium falciparum</i>Semantic proximity Read ↗

RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency.Semantic proximity Read ↗

The short conserved region-2 of LARP4 interacts with ribosome-associated RACK1 and promotes translation.Semantic proximity Read ↗

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The RACK1 scaffold protein: a dynamic cog in cell response mechanisms.Semantic proximity Read ↗

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Structure of a human pre-40S particle points to a role for RACK1 in the final steps of 18S rRNA processingSemantic proximity Read ↗

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