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Article

Effect of furfural on plasmid DNA.

Biochemistry and molecular biology international - 1 Apr 1993

Khan Q A, Hadi S M

Abstract excerpt

Furfural is a dietary mutagen and is present in various food products and beverages. We have previously shown that it induces single strand breaks in double stranded DNA that occur mainly in AT sequences. In this paper, we have examined the mutagenic effect of furfural induced lesions in the plasmid pBR322. Plasmid DNA was treated with furfural before transformation in E. coli. There was a progressive decrease in...

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PMID: 8330021

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