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Article

A comprehensive comparison of DNA replication past 2-deoxyribose and its tetrahydrofuran analog in Escherichia coli.

Nucleic acids research - 1 Jan 2004

Kroeger Kelly M, Goodman Myron F, Greenberg Marc M

Abstract excerpt

Apurinic/apyrimidinic (AP) sites are alkali labile lesions that, when encountered during DNA replication, can block polymerases or potentially result in mutagenic events. Owing to the instability of 2-deoxyribose lesions (AP), a chemically stable tetrahydrofuran analog (F) is often used as a model of abasic sites. A comparison of the two lesions in Saccharomyces cerevisiae revealed that the model lesion and...

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Identifiers

PMID: 15477395
DOI: 10.1093/nar/gkh873
PMCID: PMC524285

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Source receipt: pubmed, retrieved 7 Sept 2026.

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