Frequency analysis of HLA-DQA1 and HLA-DQB1 gene alleles and susceptibility to type 1 diabetes mellitus in Russian patients.

doi:10.1007/BF00570540

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Article

Frequency analysis of HLA-DQA1 and HLA-DQB1 gene alleles and susceptibility to type 1 diabetes mellitus in Russian patients.

Acta diabetologica - 1 Jun 1994

Gavrilov D K, Kuraeva T L, Dedov I I, Sergeev A S, Nosikov V V

Abstract excerpt

The HLA-DQA1 and DQB1 genes have recently been recognized to be strong genetic markers of susceptibility to type 1 (insulin-dependent) diabetes mellitus. The Arg52 DQA1 and non-Asp57 DQB1 alleles of these genes correlate with the disease predisposition and the Asp57 DQB1 and non-Arg52 DQA1 alleles with disease protection. We investigated 113 patients with type 1 diabetes and 121 healthy subjects from the Russian...

Topics

Adolescent
Adult
Age of Onset
Alleles
Base Sequence
Child
Child, Preschool
DNA Primers
Diabetes Mellitus, Type 1
Disease Susceptibility
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Carrier Screening

Genetic Predisposition to Disease

HLA-DQ Antigens

HLA-DQ alpha-Chains

HLA-DQ beta-Chains

Humans

Infant

Source

Open in PubMed

Identifiers

PMID: 7949227
DOI: 10.1007/BF00570540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7949227-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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