Article
Different dose effect of HLA-DQ alpha beta heterodimers in insulin-dependent diabetes mellitus and celiac disease susceptibility.
Human immunology - 1 Mar 1993
Petronzelli F, Multari G, Ferrante P, Bonamico M, Rabuffo G, Campea L, Mazzilli M C
Abstract excerpt
To compare the quantitative effect of the DQ alpha beta heterodimers DQ alpha 52 Arg+, beta 57 Asp- and DQ alpha 1*0501, beta 1*0201 on susceptibility to IDDM and CD, we characterized, at the genomic level, the DQ alpha 52 and DQ beta 57 residues of 50 IDDM Italian patients observed in Rome. The...
Topics
- Alleles
- Autoimmune Diseases
- Celiac Disease
- Child
- Codon
- DNA Probes, HLA
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- Haplotypes
- Humans
- Italy
- Mutation