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Article

Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease.

Genes and immunity - 1 Aug 2004

Koeleman B P C, Lie B A, Undlien D E, Dudbridge F, Thorsby E, de Vries R R P, Cucca F, Roep B O, Giphart M J, Todd J A

Abstract excerpt

Alleles of HLA class II genes DQB1, DQA1, and DRB1 in the MHC region are major determinants of genetic predisposition to type 1 diabetes (T1D). Several alleles of each of these three loci are associated with susceptibility or protection from disease. In addition, relative risks for some DR-DQ genotypes are not simply the sum or product of the single haplotype relative risks. For example, the risk of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15164102
DOI: 10.1038/sj.gene.6364106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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