HLA DQ alpha/beta molecule associated with the susceptibility to insulin-dependent diabetes mellitus. A model for HLA/autoimmune disease association.

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Article

HLA DQ alpha/beta molecule associated with the susceptibility to insulin-dependent diabetes mellitus. A model for HLA/autoimmune disease association.

Nouvelle revue francaise d'hematologie - 1 Jan 1990

Khalil I, Deschamps I, Lepage V, Morin L, Galibert F, Degos L, Hors J

Abstract excerpt

We have proposed a molecular model of susceptibility to Insulin-Dependent Diabetes Mellitus (IDDM) based on the proportional expression at the cell surface of the following susceptible (S-S) HLA-DQ heterodimere composed of a chain DQ alpha Arg 52 positive (S) and a chain HLA-DQ beta Asp 57 negati...

Topics

Alleles
Autoimmune Diseases
Diabetes Mellitus, Type 1
Genetic Predisposition to Disease
HLA-DQ Antigens
Humans
Models, Biological
Risk

Source

Open in PubMed

Identifiers

PMID: 2101877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2101877-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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