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Article

Dose effect of cis- and trans-encoded HLA-DQ alpha beta heterodimers in IDDM susceptibility.

Diabetes - 1 Mar 1992

Khalil I, Deschamps I, Lepage V, al-Daccak R, Degos L, Hors J

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) in whites is strongly associated with particular HLA-DQ alpha beta heterodimers composed of a DQ alpha chain with an arginine at residue 52 (Arg52+) combined to a DQ beta chain lacking an aspartic acid at residue 57 (Asp57-). With the aim of confirming this association, clarifying which heterodimers account for the highest risk of IDDM and explaining the excess risk of...

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PMID: 1551498
DOI: 10.2337/diab.41.3.378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dose effect of cis- and trans-encoded HLA-DQ alpha beta heterodimers in IDDM susceptibility.PMID 1551498Read ↗

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