Dose effect of cis- and trans-encoded HLA-DQ alpha beta heterodimers in IDDM susceptibility.

doi:10.2337/diab.41.3.378

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Article

Dose effect of cis- and trans-encoded HLA-DQ alpha beta heterodimers in IDDM susceptibility.

Diabetes - 1 Mar 1992

Khalil I, Deschamps I, Lepage V, al-Daccak R, Degos L, Hors J

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) in whites is strongly associated with particular HLA-DQ alpha beta heterodimers composed of a DQ alpha chain with an arginine at residue 52 (Arg52+) combined to a DQ beta chain lacking an aspartic acid at residue 57 (Asp57-). With the aim of confirming this association, clarifying which heterodimers account for the highest risk of IDDM and explaining the excess risk of...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cell Line
DNA
Diabetes Mellitus, Type 1
Disease Susceptibility
Gene Frequency
Genotype
HLA-D Antigens
HLA-DQ Antigens
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocompatibility Testing

Humans

Macromolecular Substances

Molecular Sequence Data

Oligodeoxyribonucleotides

Oligonucleotide Probes

Source

Open in PubMed

Identifiers

PMID: 1551498
DOI: 10.2337/diab.41.3.378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1551498-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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