Inductive effect of copper deficiency on the reversion of dedifferentiated rat hepatoma cells and on gene amplification.

doi:10.1242/jcs.107.11.3251

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Article

Inductive effect of copper deficiency on the reversion of dedifferentiated rat hepatoma cells and on gene amplification.

Journal of cell science - 1 Nov 1994

Renault E, Deschatrette J

Abstract excerpt

Cells of a dedifferentiated rat hepatoma clone were submitted in vitro to copper deficiency. This treatment caused inhibition of cell growth. In addition, in treated cultures, the frequency of differentiated revertants selected in glucose-free medium was drastically increased when compared with t...

Topics

Animals
Cell Differentiation
Cell Division
Copper
Gene Amplification
Gene Rearrangement
Liver Neoplasms, Experimental
Phenotype
Rats
Tetrahydrofolate Dehydrogenase
Time Factors
Tumor Cells, Cultured

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