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Article

Inductive effect of copper deficiency on the reversion of dedifferentiated rat hepatoma cells and on gene amplification.

Journal of cell science - 1 Nov 1994

Renault E, Deschatrette J

Abstract excerpt

Cells of a dedifferentiated rat hepatoma clone were submitted in vitro to copper deficiency. This treatment caused inhibition of cell growth. In addition, in treated cultures, the frequency of differentiated revertants selected in glucose-free medium was drastically increased when compared with the spontaneous frequency. The maximum effect was observed when cell proliferation spontaneously resumed after 20 days...

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PMID: 7699021
DOI: 10.1242/jcs.107.11.3251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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