Article
Genetic alterations in sporadic renal-cell carcinoma: molecular analyses of tumor suppressor gene harboring chromosomal regions 3p, 5q, and 17p.
World journal of urology - 1 Jan 1994
Brauch H, Pomer S, Hieronymus T, Schadt T, Löhrke H, Komitowski D
Abstract excerpt
On a genetic level, renal-cell carcinoma has been characterized by an abnormality on the short arm of chromosome 3 (3p), which suggests the inactivation of a tumor suppressor gene. One tumor suppressor gene at 3p, the von Hippel-Lindau disease gene, is implicated in tumor development of a whole s...
Topics
- Alleles
- Animals
- Carcinoma, Renal Cell
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chromosome Aberrations
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 3
- Chromosomes, Human, Pair 5
- Culture Techniques
- DNA Probes
- DNA, Neoplasm
- Deoxyribonucleases, Type II Site-Specific
- Genes, Tumor Suppressor
- Heterozygote
- Humans
- Kidney
- Kidney Neoplasms