Article
Genetic alterations in sporadic renal-cell carcinoma: molecular analyses of tumor suppressor gene harboring chromosomal regions 3p, 5q, and 17p.
World journal of urology - 1 Jan 1994
Brauch H, Pomer S, Hieronymus T, Schadt T, Löhrke H, Komitowski D
Abstract excerpt
On a genetic level, renal-cell carcinoma has been characterized by an abnormality on the short arm of chromosome 3 (3p), which suggests the inactivation of a tumor suppressor gene. One tumor suppressor gene at 3p, the von Hippel-Lindau disease gene, is implicated in tumor development of a whole spectrum of hereditary neoplasms, including renal-cell carcinoma. It is not clear whether the same tumor suppressor gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.