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Article

Individual differences in lung cancer susceptibility in relation to polymorphisms of P-450IA1 gene and cigarette dose.

Princess Takamatsu symposia - 1 Jan 1990

Kawajiri K, Nakachi K, Imai K, Hayashi S, Watanabe J

Abstract excerpt

Individual differences in susceptibility to chemical carcinogens are one of the most important host factors in the development of human cancer. We studied the etiological association of lung cancer with the DNA polymorphisms of P-450 IA1 gene, because cytochrome P-450IA1 is responsible for the metabolic activation of benzo(a)pyrene and other procarcinogens in cigarette smoking to the ultimate forms in the...

Topics

Blotting, Southern
Carcinoma, Squamous Cell
Chromosome Mapping
Cytochrome P-450 Enzyme System
Dose-Response Relationship, Drug
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Genetic

Smoking

Source

Identifiers

PMID: 2134690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2134690-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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