Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose.

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Article

Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose.

Cancer research - 1 Oct 1991

Nakachi K, Imai K, Hayashi S, Watanabe J, Kawajiri K

Abstract excerpt

Cytochrome P450IA1 is responsible for the metabolic activation of benzo(a)pyrene in cigarette smoke; an association of lung cancer with DNA polymorphisms of P450IA1 gene was shown in our previous study. In this paper, we investigated the interindividual difference of genetically determined susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose. We first compared the total...

Topics

Adenocarcinoma
Aged
Carcinoma, Non-Small-Cell Lung
Carcinoma, Small Cell
Carcinoma, Squamous Cell
Case-Control Studies
Cytochrome P-450 Enzyme System
Dose-Response Relationship, Drug
Female
Gene Frequency
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Lung Neoplasms

Male

Middle Aged

Odds Ratio

Risk

Source

Open in PubMed

Identifiers

PMID: 1655248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1655248-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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