Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of RB germline mutations using exon-by-exon heteroduplex analysis compared with SSCP.

Yan ke xue bao = Eye science - 1 Sept 1996

Zhang Q, Minoda K

Abstract excerpt

PURPOSE: To compare heteroduplex analysis with SSCP and to develop a simple and effective method for mutational screening of RB gene. MATERIALS AND METHODS: Leukocyte DNA was prepared from 12 unrelated Japanese patients with hereditary retinoblstoma. PCR combined with simultaneous nonisotopic heteroduplex and SSCP analysis was used to screen leukocyte DNA for such mutations, exon-by-exon, without the use of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Neoplasm
Share to Exons
Share to Genes, Retinoblastoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Nucleic Acid Heteroduplexes

Share to Polymorphism, Single-Stranded Conformational

Share to Retinoblastoma

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 9639842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of RB germline mutations using exon-by-exon heteroduplex analysis compared with SSCP.PMID 9639842Read ↗

[Gene diagnosis and genetic counselling of Rb gene mutations in retinoblastoma patients and their family members].Semantic proximity Read ↗

Mutation detection and genetic counseling in retinoblastoma using heteroduplex analysis.Semantic proximity Read ↗

Detection of heterozygous mutations in the RB1 gene in retinoblastoma patients using single-strand conformation polymorphism analysis and polymerase chain reaction sequencing.Semantic proximity Read ↗

[Mutations of several tumor suppressor genes in primary retinoblastoma].Semantic proximity Read ↗

Identification of three novel RB1 mutations in Brazilian patients with retinoblastoma by "exon by exon" PCR mediated SSCP analysis.Semantic proximity Read ↗

Identification of germline mutations in the RB1 gene by denaturant gradient gel electrophoresis and polymerase chain reaction direct sequencing.Semantic proximity Read ↗

[Spectrum and frequencies of RB1 gene structural defects in retinoblastoma].Semantic proximity Read ↗

SSCP/heteroduplex analysis.Semantic proximity Read ↗

A molecular study of first and second RB1 mutational hits in retinoblastoma patients.Semantic proximity Read ↗

Direct cycle sequencing of mutated alleles detected by PCR single-strand conformation polymorphism analysis.Semantic proximity Read ↗

[Diagnosis of a predisposition of retinoblastoma at the DNA level].Semantic proximity Read ↗

Screening for mutations by RNA single-strand conformation polymorphism (rSSCP): comparison with DNA-SSCP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.