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SεSμ and SεSγ Switch Circles in Human Nasal Mucosa Following Ex Vivo Allergen Challenge: Evidence for Direct as Well as Sequential Class Switch Recombination

1 Oct 2003

Abstract excerpt

B cells switch to IgE under the influence of IL-4, IL-13, and CD40 costimulation through a multistep process involving epsilon germline transcription and class switch recombination. Classically, switching has been considered an event restricted to lymphoid tissues; however, epsilon germline transcripts (I(initiator)epsilon RNA) have been observed within lung, sinus, and nasal tissue of individuals with asthma,...

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PMID: 14500683
DOI: 10.4049/jimmunol.171.7.3816

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SεSμ and SεSγ Switch Circles in Human Nasal Mucosa Following Ex Vivo Allergen Challenge: Evidence for Direct as Well as Sequential Class Switch RecombinationPMID 14500683Read ↗

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