Article
The -2518A>G promoter polymorphism in the CCL2 gene is not associated with systemic sclerosis susceptibility or phenotype: results from a multicenter study of European Caucasian patients.
Human immunology - 1 Feb 2009
Radstake Timothy R D J, Vonk Madelon C, Dekkers Marieke, Schijvenaars Mascha M V A P, Treppichio William L, Lafyatis Robert, Riemekasten Gabriela, van den Hoogen Frank, Coenen Marieke J H
Abstract excerpt
A single nucleotide polymorphism (SNP) of the gene encoding monocyte chemoattractant protein-1 (MCP-1, CCL2) has previously been suggested to be involved in the susceptibility of systemic sclerosis (SSc). Here we have tested whether the -2518A>G CCL2 variant is associated with SSc susceptibility and/or phenotype using a cohort of SSc patients (n = 345). Clinical data from SSc patients attending rheumatology...
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