Article
Expansion and tumour specific cytokine secretion of bryostatin-activated T-cells from cryopreserved axillary lymph nodes of breast cancer patients.
Surgical oncology - 1 Oct 1993
Lind D S, Tuttle T M, Bethke K P, Frank J L, McCrady C W, Bear H D
Abstract excerpt
Current adoptive immunotherapy strategies in cancer patients require large numbers of activated T-cells and are limited by the availability of autologous tumour. We describe a novel method of T-cell activation that produced relatively rapid, high-fold expansion of stored, frozen lymphocytes obtai...
Topics
- Adjuvants, Immunologic
- Axilla
- Breast Neoplasms
- Bryostatins
- Cryopreservation
- Female
- Humans
- Immunotherapy
- Interferon-gamma
- Ionomycin
- Lactones
- Lymph Nodes
- Lymphocyte Activation
- Lymphocyte Subsets
- Lymphocytes, Tumor-Infiltrating
- Macrolides
- Phenotype
- T-Lymphocytes