Article
Activation and growth of murine tumor-specific T-cells which have in vivo activity with bryostatin 1.
Cancer research - 1 Feb 1992
Tuttle T M, Inge T H, Bethke K P, McCrady C W, Pettit G R, Bear H D
Abstract excerpt
We examined the ability of bryostatin 1 (Bryo), a novel protein kinase C activator, plus ionomycin (Io), a calcium ionophore, to activate T-cells with specific antitumor activity. Lymphocytes from the draining lymph nodes (DLN) of MCA-105 tumor-bearing host mice were stimulated with Bryo/Io, either fresh or after in vitro stimulation with autologous tumor, and then were incubated in interleukin-2 at 20 units/ml....
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Surface
- Antineoplastic Agents
- Bryostatins
- Cytotoxicity, Immunologic
- Female
- Immunotherapy, Adoptive
- Lactones
- Lung Neoplasms
- Lymphocyte Activation