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Article

Thymoglobulin, interferon-γ and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures.

Journal of translational medicine - 7 Dec 2010

Bonanno Giuseppina, Iudicone Paola, Mariotti Andrea, Procoli Annabella, Pandolfi Annino, Fioravanti Daniela, Corallo Maria, Perillo Alessandro, Scambia Giovanni, Pierelli Luca, Rutella Sergio

Abstract excerpt

BACKGROUND: Cytokine-induced killer (CIK) cells are typically differentiated in vitro with interferon (IFN)-γ and αCD3 monoclonal antibodies (mAb), followed by the repeated provision of interleukin (IL)-2. It is presently unknown whether thymoglobulin (TG), a preparation of polyclonal rabbit γ immunoglobulins directed against human thymocytes, can improve the generation efficiency of CIK cells compared with αCD3...

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Identifiers

PMID: 21138560
DOI: 10.1186/1479-5876-8-129
PMCID: PMC3004824

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Source receipt: pubmed, retrieved 7 Sept 2026.

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