Article
Different functional domains of TAFII250 modulate expression of distinct subsets of mammalian genes.
Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2000
O'Brien T, Tjian R
Abstract excerpt
The TATA box-binding protein-associated factors (TAFs) are thought to play an essential role in eukaryotic RNA polymerase II transcription by mediating the expression of distinct subsets of genes. In hamster ts13 cells, a single amino acid change in TAF(II)250, which disrupts its acetyl-transferase activity at the restrictive temperature, alters the transcription of specific genes involved in cell cycle control....
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