Article
A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice.
European journal of immunology - 1 Feb 1994
Miyawaki S, Nakamura Y, Suzuka H, Koba M, Yasumizu R, Ikehara S, Shibata Y
Abstract excerpt
We have found a new spontaneous autosomal recessive mutation in mice that causes a systemic absence of lymph nodes and Peyer's patches. The name "alymphoplasia", with the gene symbol "aly", is proposed for this mutant. The spleen of aly/aly mice is devoid of well-defined lymphoid follicles, and t...
Topics
- Animals
- Bone Marrow Transplantation
- H-2 Antigens
- Immunologic Deficiency Syndromes
- Immunophenotyping
- Lymph Nodes
- Lymphoid Tissue
- Mice
- Mice, Inbred C57BL
- Mutation