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Article

NF-κB-inducing kinase contributes to normal development of cortical thymic epithelial cells: its possible role in shaping a proper T-cell repertoire.

Immunology - 1 Jun 2020

Eshima Koji, Misawa Kana, Ohashi Chihiro, Noma Haruka, Iwabuchi Kazuya

Abstract excerpt

Nuclear factor (NF)-κB-inducing kinase (NIK) is known to be a critical regulator of multiple aspects of the immune response. Although the role of NIK in the development of medullary thymic epithelial cells (mTECs) has been well documented, the impact of NIK on the differentiation and function of cortical thymic epithelial cells (cTECs) remains ambiguous. To investigate the possible involvement of NIK in cTEC...

Topics

Animals
Bone Marrow Transplantation
Cell Differentiation
Clonal Selection, Antigen-Mediated
Epithelial Cells
Female
Flow Cytometry
Gene Expression Profiling
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Transgenic

Mutation

Protein Serine-Threonine Kinases

T-Lymphocytes

Thymus Gland

Transplantation Chimera

Source

Open in PubMed Open full text

Identifiers

PMID: 32145062
DOI: 10.1111/imm.13186
PMCID: PMC7218659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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