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Article

Splenic extramedullary hemopoiesis caused by a dysfunctional mutation in the NF-κB-inducing kinase gene.

Biochemical and biophysical research communications - 4 Nov 2011

Shinzawa Miho, Maruyama Yuya, Qin Junwen, Akiyama Nobuko, Miyauchi Maki, Yanai Hiromi, Takami Masamichi, Inoue Jun-Ichiro, Akiyama Taishin

Abstract excerpt

NF-κB-inducing kinase (NIK) plays critical roles in the development of lymph nodes and Peyer's patches, and microarchitecture of the thymus and spleen via NF-κB activation. Alymphoplasia (aly/aly) mice have a point mutation in the NIK gene that causes a defect in the activation of an NF-κB member RelB. Here, we developed a novel method to determine the aly mutation by genetic typing using PCR. This method...

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PMID: 22005462
DOI: 10.1016/j.bbrc.2011.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Splenic extramedullary hemopoiesis caused by a dysfunctional mutation in the NF-κB-inducing kinase gene.PMID 22005462Read ↗

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