Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice.

doi:10.1093/intimm/8.7.1067

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Article

Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice.

International immunology - 1 Jul 1996

Shinkura R, Matsuda F, Sakiyama T, Tsubata T, Hiai H, Paumen M, Miyawaki S, Honjo T

Abstract excerpt

The alymphoplasia (aly) mutation of mice causes the systemic absence of lymph nodes, Peyer's patches and well-defined lymphoid follicles in the spleen. We found that antibody responses are elicited, albeit weakly, to either T cell-dependent or T cell-independent antigen by aly/aly mutants. Howeve...

Topics

Amino Acid Sequence
Animals
Antibody Formation
Antibody Specificity
Antigens, T-Independent
Base Sequence
Genetic Variation
Germinal Center
Immunoglobulin Class Switching
Immunologic Deficiency Syndromes
Lymph Nodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoid Tissue

Mice

Mice, Mutant Strains

Molecular Sequence Data

Mutation

Peyer's Patches

Spleen

Source

Open in PubMed

Identifiers

PMID: 8757952
DOI: 10.1093/intimm/8.7.1067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8757952-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice.PMID 8757952Read ↗

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