Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms' tumour and gigantism.

doi:10.1038/ng1293-408

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Article

Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms' tumour and gigantism.

Nature genetics - 1 Dec 1993

Ogawa O, Becroft D M, Morison I M, Eccles M R, Skeen J E, Mauger D C, Reeve A E

Abstract excerpt

We have examined the imprinting of the insulin-like growth factor II gene (IGF2) in ten normal kidney samples from children with renal embryonal neoplasms. In kidney samples from nine children with normal growth profiles, IGF2 mRNA was transcribed monoallelically, consistent with normal imprintin...

Topics

Alleles
Genes, Wilms Tumor
Gigantism
Humans
Insulin-Like Growth Factor II
Kidney Neoplasms
Polymerase Chain Reaction
Polymorphism, Genetic
RNA, Messenger

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