Article
Insulin-like growth factor 2 and overgrowth: molecular biology and clinical implications.
Molecular medicine today - 1 Mar 1998
Morison I M, Reeve A E
Abstract excerpt
The insulin-like growth factors, IGF1 and IGF2, play a fundamental role in human fetal growth. Of the growth disorders that involve excessive growth, many could be attributable to overexpression of IGF2. Because one copy of the IGF2 gene is silenced by genomic imprinting, several different molecu...
Topics
- Animals
- Beckwith-Wiedemann Syndrome
- Embryonic and Fetal Development
- Growth Disorders
- Humans
- Insulin-Like Growth Factor II
- Mutation
- Syndrome
- Wilms Tumor