Aberrant imprinting of the insulin-like growth factor II receptor gene in Wilms' tumor.

doi:10.1038/sj.onc.1200926

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Article

Aberrant imprinting of the insulin-like growth factor II receptor gene in Wilms' tumor.

Oncogene - 6 Mar 1997

Xu Y Q, Grundy P, Polychronakos C

Abstract excerpt

Wilms' tumor (WT) is an embryonal renal malignancy, which overexpresses insulin-like growth factor II (IGF-II), a fetal mitogen. Relaxation of parental imprinting of IGF2, the gene encoding IGF-II, is found in Wilms' tumors, suggesting an important role for IGF2 dosage in tumorigenesis. The IGF2R...

Topics

Alleles
Fathers
Genomic Imprinting
Humans
Kidney
Kidney Neoplasms
Mothers
Polymerase Chain Reaction
Polymorphism, Genetic
Receptor, IGF Type 2
Wilms Tumor

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