Article
Aberrant imprinting of the insulin-like growth factor II receptor gene in Wilms' tumor.
Oncogene - 6 Mar 1997
Xu Y Q, Grundy P, Polychronakos C
Abstract excerpt
Wilms' tumor (WT) is an embryonal renal malignancy, which overexpresses insulin-like growth factor II (IGF-II), a fetal mitogen. Relaxation of parental imprinting of IGF2, the gene encoding IGF-II, is found in Wilms' tumors, suggesting an important role for IGF2 dosage in tumorigenesis. The IGF2R gene encodes a nonmitogenic receptor which targets IGF-II to the lysosomes for degradation and, therefore, inhibits...
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