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Article

Role of genomic imprinting in Wilms' tumour and overgrowth disorders.

Medical and pediatric oncology - 1 Nov 1996

Reeve A E

Abstract excerpt

Activation of the silent maternal IGF2 allele has recently been found in approximately half of Wilms' tumour (WTs) examined. This process of imprint relaxation leads to biallelic expression of IGF2 and it has been suggested that this is a key event in the onset of some WTs. Although it has previously been proposed that the 11p15 chromosome region contains a growth-promoting gene and a tumour suppressor gene, the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8827076
DOI: 10.1002/(SICI)1096-911X(199611)27:5<470::AID-MPO14>3.0.CO;2-E

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Role of genomic imprinting in Wilms' tumour and overgrowth disorders.PMID 8827076Read ↗

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Beck-Wiedemann syndrome and Wilms' tumour.Semantic proximity Read ↗

Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.Semantic proximity Read ↗

Human IGF2 Gene Epigenetic and Transcriptional Regulation: At the Core of Developmental Growth and Tumorigenic BehaviorSemantic proximity Read ↗

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumourSemantic proximity Read ↗

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