Article
Role of genomic imprinting in Wilms' tumour and overgrowth disorders.
Medical and pediatric oncology - 1 Nov 1996
Reeve A E
Abstract excerpt
Activation of the silent maternal IGF2 allele has recently been found in approximately half of Wilms' tumour (WTs) examined. This process of imprint relaxation leads to biallelic expression of IGF2 and it has been suggested that this is a key event in the onset of some WTs. Although it has previo...
Topics
- Alleles
- Animals
- Beckwith-Wiedemann Syndrome
- Chromosomes, Human, Pair 11
- Disease Models, Animal
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genomic Imprinting
- Gigantism
- Growth
- Growth Disorders
- Humans
- Insulin-Like Growth Factor II
- Kidney Neoplasms
- Mice
- Muscle Proteins
- RNA, Long Noncoding
- RNA, Untranslated