Article
Identification of genomic regions required for DNA replication during Drosophila embryogenesis.
Genetics - 1 Nov 1993
Smith A V, King J A, Orr-Weaver T L
Abstract excerpt
A collection of Drosophila deficiency stocks was examined by bromodeoxyuridine (BrdU) labeling of embryos to analyze the DNA replication patterns in late embryogenesis. This permitted us to screen 34% of the genome for genes that when absent in homozygous deficiencies affect the cell cycle or DNA replication. We found three genomic intervals that when deleted result in cessation of DNA replication in the embryo,...
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