The 20S proteasome mediates the degradation of mouse and yeast ornithine decarboxylase in yeast cells.

doi:10.1016/0014-5793(94)80199-1

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Article

The 20S proteasome mediates the degradation of mouse and yeast ornithine decarboxylase in yeast cells.

FEBS letters - 17 Jan 1994

Mamroud-Kidron E, Rosenberg-Hasson Y, Rom E, Kahana C

Abstract excerpt

Ornithine decarboxylase (ODC), a key enzyme in the biosynthesis of polyamines, is one of the most rapidly degraded proteins in mammalian cells. Recently it has been demonstrated that mammalian ODC is degraded in vitro by the 26S protease that contains the 20S proteasome as its catalytic core, in...

Topics

Animals
Cloning, Molecular
Cysteine Endopeptidases
Gene Transfer Techniques
Mice
Multienzyme Complexes
Mutation
Ornithine Decarboxylase
Proteasome Endopeptidase Complex
Recombinant Proteins
Saccharomyces cerevisiae
Transformation, Genetic

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