Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.

doi:10.1002/j.1460-2075.1991.tb07982.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.

The EMBO journal - 1 Mar 1991

Heinemeyer W, Kleinschmidt J A, Saidowsky J, Escher C, Wolf D H

Abstract excerpt

Proteinase yscE is the yeast equivalent of the proteasome, a multicatalytic-multifunctional proteinase found in higher eukaryotic cells. We have isolated three mutants affecting the proteolytic activity of proteinase yscE. The mutants show a specific reduction in the activity of the complex against peptide substrates with hydrophobic amino acids at the cleavage site and define two complementation groups, PRE1 and...

Topics

Amino Acid Sequence
Base Sequence
Chromosome Deletion
Chromosomes, Fungal
Cloning, Molecular
Cysteine Endopeptidases
Genes, Fungal
Genetic Complementation Test
Kinetics
Macromolecular Substances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Protein Biosynthesis

Restriction Mapping

Saccharomyces cerevisiae

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2001673
DOI: 10.1002/j.1460-2075.1991.tb07982.x
PMCID: PMC452684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2001673-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.PMID 2001673Read ↗

The proteasome/multicatalytic-multifunctional proteinase. In vivo function in the ubiquitin-dependent N-end rule pathway of protein degradation in eukaryotes.Semantic proximity Read ↗

Mutations in the yeast proteasome beta-type subunit Pre3 uncover position-dependent effects on proteasomal peptidase activity and in vivo function.Semantic proximity Read ↗

Proteasome subunit α1 overexpression preferentially drives canonical proteasome biogenesis and enhances stress tolerance in yeastSemantic proximity Read ↗

Biogenesis of the yeast vacuole (lysosome). The use of active-site mutants of proteinase yscA to determine the necessity of the enzyme for vacuolar proteinase maturation and proteinase yscB stability.Semantic proximity Read ↗

Metacaspase Yca1 is required for clearance of insoluble protein aggregates.Semantic proximity Read ↗

Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeastSemantic proximity Read ↗

Proteinase yscD (oligopeptidase yscD). Structure, function and relationship of the yeast enzyme with mammalian thimet oligopeptidase (metalloendopeptidase, EP 24.15).Semantic proximity Read ↗

Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast.Semantic proximity Read ↗

Proteasome beta-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function.Semantic proximity Read ↗

Identification of an essential gene, l(3)73Ai, with a dominant temperature-sensitive lethal allele, encoding a Drosophila proteasome subunit.Semantic proximity Read ↗

Ssy5 is a signaling serine protease that exhibits atypical biogenesis and marked S1 specificity.Semantic proximity Read ↗

Proteasomes: unfoldase-assisted protein degradation machinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.