Article
Eukaryotic 20S proteasome catalytic subunit propeptides prevent active site inactivation by N-terminal acetylation and promote particle assembly.
The EMBO journal - 1 Jul 1999
Arendt C S, Hochstrasser M
Abstract excerpt
Proteins targeted for degradation by the ubiquitin-proteasome system are degraded by the 26S proteasome. The core of this large protease is the 20S proteasome, a barrel-shaped structure made of a stack of four heptameric rings. Of the 14 different subunits that make up the yeast 20S proteasome, three have proteolytic active sites: Doa3/beta5, Pup1/beta2 and Pre3/beta1. Each of these subunits is synthesized with...
Topics
- Acetylation
- Amino Acid Sequence
- Arylamine N-Acetyltransferase
- Binding Sites
- Catalysis
- Catalytic Domain
- Cell Division
- Cysteine Endopeptidases
- Endopeptidases
- Fungal Proteins
- Isoenzymes
- Molecular Sequence Data
- Multienzyme Complexes
- Peptide Fragments