Article
The proteasome/multicatalytic-multifunctional proteinase. In vivo function in the ubiquitin-dependent N-end rule pathway of protein degradation in eukaryotes.
FEBS letters - 11 May 1992
Richter-Ruoff B, Heinemeyer W, Wolf D H
Abstract excerpt
Proteinase yscE, the proteasome/multicatalytic-multifunctional proteinase of yeast had been shown to function in stress response and in the degradation of ubiquitinated proteins [(1991) EMBO J. 10, 555-562]. A well-defined set of proteins degraded via ubiquitin-mediated proteolysis are the substrates of the N-end rule pathway [(1986) Science 234, 179-186; (1989) Science 243, 1576-1583]. We show that mutants...
Topics
- Catalysis
- Chymotrypsin
- Cysteine Endopeptidases
- Multienzyme Complexes
- Mutation
- Proteasome Endopeptidase Complex
- Proteins
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae
- Substrate Specificity