Differentiation of BA-HAN-1C rhabdomyosarcoma cells is controlled by a pertussis toxin sensitive signaling pathway.

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Article

Differentiation of BA-HAN-1C rhabdomyosarcoma cells is controlled by a pertussis toxin sensitive signaling pathway.

Cellular & molecular biology research - 1 Jan 1993

Arnold H H, Salminen A

Abstract excerpt

BA-Han-1C rat rhabdomyosarcoma cells grow with a transformed phenotype and do not differentiate efficiently. Here, we report that these cells can be induced with pertussis toxin (PTX) to rapidly express the myogenin gene and form terminally differentiated myotubes. Potential targets for the effec...

Topics

Adenosine Diphosphate
Animals
Cell Differentiation
Cell Transformation, Neoplastic
Cyclic AMP
Fibroblast Growth Factor 2
GTP Phosphohydrolases
GTP-Binding Proteins
Gene Expression Regulation
Muscles
Myogenin
Pertussis Toxin
Phenotype
Rats
Rhabdomyosarcoma
Ribose
Signal Transduction
Suramin

Source

Open in PubMed

Identifiers

PMID: 8293037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8293037-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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