Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autocrine growth hormone production prevents apoptosis and inhibits differentiation in C2C12 myoblasts.

Cellular signalling - 1 Jun 2003

Segard Haniaa Bouzinba, Moulin Stéphanie, Boumard Stéphanie, Augier de Crémiers Catherine, Kelly Paul A, Finidori Joëlle

Abstract excerpt

Although C2C12 myoblasts express low levels of growth hormone receptor (GHR), we failed to see any effect of exogenous growth hormone (GH) on cell proliferation or differentiation. C2C12 cells stably overexpressing (sixfold) more in GHR (C2C12(GHR)) grew faster than parental cells in media containing 2% serum, and proliferated while parental cells died, in the absence of serum. These effects were independent of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Autocrine Communication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Culture Media, Serum-Free

Share to Growth Hormone

Share to Insulin-Like Growth Factor I

Share to Myoblasts

Share to Receptors, Somatotropin

Share to Transfection

Source

Identifiers

PMID: 12681449
DOI: 10.1016/s0898-6568(03)00005-6

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autocrine growth hormone production prevents apoptosis and inhibits differentiation in C2C12 myoblasts.PMID 12681449Read ↗

Sprouty-2 overexpression in C2C12 cells confers myogenic differentiation properties in the presence of FGF2.Semantic proximity Read ↗

Interleukin-6 Induces Myogenic Differentiation via JAK2-STAT3 Signaling in Mouse C2C12 Myoblast Cell Line and Primary Human MyoblastsSemantic proximity Read ↗

Phenotypic characteristics of adipocyte-like cells generated from C2C12 myoblasts cultured with chicken serum.Semantic proximity Read ↗

Myostatin acts as an autocrine/paracrine negative regulator in myoblast differentiation from human induced pluripotent stem cellsSemantic proximity Read ↗

The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy.Semantic proximity Read ↗

Insulin-like growth factor I (IGF-I) receptor overexpression abolishes the IGF requirement for differentiation and induces a ligand-dependent transformed phenotype in C2 inducible myoblasts.Semantic proximity Read ↗

Stimulation of C2C12 myoblast growth by basic fibroblast growth factor and insulin-like growth factor 1 can occur via mitogen-activated protein kinase-dependent and -independent pathways.Semantic proximity Read ↗

Activation of growth hormone receptor delivers an antiapoptotic signal: evidence for a role of Akt in this pathway.Semantic proximity Read ↗

Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts.Semantic proximity Read ↗

Roles of insulin-like growth factor (IGF) receptors and IGF-binding proteins in IGF-II-induced proliferation and differentiation of L6A1 rat myoblasts.Semantic proximity Read ↗

Differential Response to Exogenous and Endogenous Myostatin in Myoblasts Suggests that Myostatin Acts as an Autocrine Factor<i>in Vivo</i>Semantic proximity Read ↗

Positive regulation of skeletal myogenesis by R-Ras.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.