Article
Evidence for allelic heterogeneity in familial early-onset Alzheimer's disease.
The British journal of psychiatry : the journal of mental science - 1 Apr 1991
van Duijn C M, van Broeckhoven C, Hardy J A, Goate A M, Rossor M N, Vandenberghe A, Martin J J, Hofman A, Mullan M J
Abstract excerpt
Age of onset was examined for 139 members of 30 families affected by early-onset AD. Most (77%) of the variance of age of onset derived from differences between rather than within families. The constancy of age of onset within families was also observed in an analysis restricted to families derived from a population-based epidemiological study with complete ascertainment of early-onset AD. Furthermore, we...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Chromosome Aberrations
- Chromosome Disorders
- Chromosomes, Human, Pair 21
- Genes, Dominant
- Genetic Carrier Screening
- Genetic Linkage
- Genetic Markers