Article
Effects of Multiple Genetic Loci on Age at Onset in Frontotemporal Dementia.
Journal of Alzheimer's disease : JAD - 1 Jan 2017
Ferrari Raffaele, Grassi Mario, Graziano Francesca, Palluzzi Fernando, Archetti Silvana, Bonomi Elisa, Bruni Amalia C, Maletta Raffaele G, Bernardi Livia, Cupidi Chiara, Colao Rosanna, Rainero Innocenzo, Rubino Elisa, Pinessi Lorenzo, Galimberti Daniela, Scarpini Elio, Serpente Maria, Nacmias Benedetta, Piaceri Irene, Bagnoli Silvia, Rossi Giacomina, Giaccone Giorgio, Tagliavini Fabrizio, Benussi Luisa, Binetti Giuliano, Ghidoni Roberta, Singleton Andrew, Hardy John, Momeni Parastoo, Padovani Alessandro, Borroni Barbara
Abstract excerpt
In frontotemporal dementia (FTD), age at disease onset (AAO) is unpredictable in both early and late-onset cases; AAO variability is found even in autosomal dominant FTD. The present study was aimed at identifying genetic modifiers modulating AAO in a large cohort of Italian FTD patients. We conducted an association analysis on 411 FTD patients, belonging to 7 Italian Centers, and for whom AAO was available....
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