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Article

New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study.

Molecular and cellular biology - 1 Oct 2005

Krawczyk Michal, Masternak Krzysztof, Zufferey Madeleine, Barras Emmanuèle, Reith Walter

Abstract excerpt

The transcription factors RFX and CIITA are major players in regulation of the expression of all classical and nonclassical major histocompatibility complex class II (MHC-II) genes. RFX nucleates the formation of a multiprotein complex, called the MHC-II enhanceosome, on MHC-II promoters. Assembly of this enhanceosome is an obligatory step for recruitment of the coactivator CIITA and thus for activation of MHC-II...

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Identifiers

PMID: 16166641
DOI: 10.1128/MCB.25.19.8607-8618.2005
PMCID: PMC1265745

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study.PMID 16166641Read ↗

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